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Silicone Adhesives and Primers for Bonding in Healthcare Applications
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This paper provides a general discussion of silicone primers and adhesives for the medical device industry. Adhesion theory is discussed in detail to provide a background for the subsequent discussion of silicone primer and adhesive chemistries. The paper provides information on some substrates common to the medical device industry and gives quantitative data on silicones adhesion to various substrates.
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Silicone Pressure Sensitive Adhesives and Primers versus Tacky Gels
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By definition, transdermal, drug-delivery applications mandate the use of adequate adhesive systems to not only keep the pharmaceutical agent in contact with the intended surface, but to facilitate sustained, controlled delivery. Engineers who must determine which silicone chemistry is optimal for their device have a few options. While pressuresensitive silicone adhesives (PSAs) have typically been considered optimal for transdermal applications, silicone gel technology has emerged as an excellent option.
To make an educated decision regarding chemistry choices, it's vital to understand the differences between silicone PSAs and gels in both composition and physical performance. After reviewing supplied forms and basic chemistry, NuSil Technology, LLC, compared these factors, as well as peel and tack data, to illustrate the strengths, advantages and disadvantages of each technology.
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Silicones as a Material of Choice for Drug Delivery Applications
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This paper will investigate the benefits of using silicone in drug delivery applications. This investigation first provides an overview of how versatile of a material silicone can be to the drug delivery industry. An examination of the chemistry of silicone, the multiple material composition options and various cure chemistries demonstrates how silicone can be tailored to fit specific drug delivery applications. Then, a general investigation of the way a silicone interacts with a drug, in regards to compatibility and potential interactions, exhibits silicone's ability to deliver pharmaceutical agents. The paper will also review factors that have made silicones the materials of choice in the medical device industry, particularly for long-term implantable devices. Examples of applications demonstrate the reasons for choosing silicone over a different material. The paper will finish with real world examples of current drug delivery applications incorporating a silicone, such as hormone replacement therapies, to manifest the benefits of using silicone in drug delivery applications.
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