Pharmaceutical and Medical Packaging News
Magazine
PMPN Article Index
Originally Published PMPN November 2005
Product Update
Integrating Desiccants
Product-testing desiccants can be inserted or integrated into packages.
Desiccating Lamination
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A moisture-scavenging lamination can be used to manufacture preformed pouches, eliminating the need for sachet insertions. The pouch controls internal-package relative humidity to less than 10% for the life of the scavenger capacity. The scavenger is incorporated into the heat-seal layer of the lamination. This lamination performs the same function as physical desiccants such as sachets or hydration salts. It is designed to reduce the risk of moisture release-back. It also reduces the need for and costs of manufacturing and labor associated with other forms of desiccants. The pouch is also designed to enhance shelf life by improving protection against foil fracture, pinholes, and package-edge moisture penetration. The desiccating pouch uses resins and additives with no surface contaminants or residuals. Alcan Packaging—Medical Flexibles, Neenah, WI; 773/399-8450; www.alcanpackaging.com.
Desiccant Canister
A desiccant canister used for high-speed automatic insertion absorbs gases through both Tyvek ends of the cylinder. The Dri-Mac canister design is an alternative to the single-end canister, which, if not dosed correctly or if inverted during transit, can be rendered useless. The canisters are sonically welded at the ends and are inspected by three vision systems. Made of natural HDPE, they can withstand irradiation for sterilization. Canisters are available in sizes from 0.5 to 3 g. Absorbent fills available include silica gel (indicating and nonindicating), molecular sieve, and activated carbon. Silgel Packaging Ltd., Telford, Shropshire, UK; +44 1952 588558; www.silgel.co.uk.
Sorbents
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An oxygen-absorbing sorbent protects drugs from oxygen- and moisture-related degradation to ensure product integrity. StabilOx sorbents are designed to extend a product's shelf life and improve consumer safety. The sorbents contain iron oxide–forming ingredients that are nontoxic and nonreactive with solid-dose pharmaceutical formulations. They also prevent cracking and leeching associated with overdrying. They can be used in HDPE bottles, trays, and blister packaging. The sorbents are available in different sizes of tablets, packets, and self-adhesive forms for blister packaging. They can be used with automated dispensing equipment in high-speed packaging lines. Multisorb Technologies, Buffalo, NY; 888/767-2368; www.multisorb.com.
Desiccating Packaging
A company has integrated desiccants and silica gel into product packaging. The company manufactures vials and containers with desiccants co-injected in the lining. The containers are airtight and leakproof. They are available in any size or color. The manufacturer also offers desiccant sheets that can be inserted into packaging. The sheet material is produced in various sizes, thicknesses, and formulations to suit customers' needs. A desiccant film with adhesive backing is also available. The film can act as a warning, changing color from blue to pink when absorption capacity is reached. Desiccants are also available in any custom injection-molded shape, such as tablets, wafers, or beads. Absorption rates, capacities, and colors can be varied based on customers' product requirements. CSP Technologies, Auburn, AL; 334/887-8300; www.csptechnologies.com.
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