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Medical Product Manufacturing News
 

Archive for July, 2009

Scientists Seek to Power Medical Implants with Piezoelectric Materials

Friday, July 31st, 2009

University of Houston (UH; Houston) scientists are studying flexoelectricity in an effort to make piezoelectric materials that could be used to power such electronic devices as biomedical implants. Currently used in commercial applications such as gas lighters in homes and actuators, the research team hopes to use the materials to create an lightweight, environmentally friendly energy supply for nanodevices.

Using their understanding of flexoelectricity, the team is experiementing at the nanoscale to make ordinary material exhibit the piezoelectric effect. Associate professor Pradeep Sharma and Ramanan Krishnamoorti, UH chair of the chemical and biomolecular engineering department, are working together to embed classes of nanostructures in polymers to create unusual types of piezoelectrics. The flexoelectric effect is mainly a function of size, and materials with nanoscale features exhibit a much larger flexoelectric effect, according to Sharma.

“You can make the effect even larger [in materials that are already piezoelectric],” Sharma says. The piezoelectricity in barium titanate, for example, can be increased by 300% when the material is reduced to a 2-nm beam and pressure is applied, he adds.

In addition to the challenge of fabricating these piezoelectric nanostructures, the team—and the technology—are hindered by the lack of methods for storing the electricity produced by the materials. The amount of power that can be harvested is still too low to actually power wearable devices, unless efficient electric storage solutions, like nanocapacitors, also are conceived, according to UH professor Ken White.

New Equipment Enables Supplier to Expand Offerings

Thursday, July 30th, 2009

The addition of a Cincinnati Milacron 440-t horizontal injection molding machine will enable Vaupell Northeast Molding & Tooling (Agawam, MA) to offer its customers larger-scale molded parts. By installing the machine in its 105,000-sq ft facility, the supplier hopes to attract new customers who need larger parts, both locally and worldwide. The machine can hold a mold up to 29 × 29 × 28/10 in. with a maximum shot size of 56 oz. With the addition of the new equipment, the plant has a total of 45 injection molding machines with capacities ranging from 55 to 440 t.

“This machine simply adds a greater range of capabilities to our existing facility,” remarks Thom Murphy, Vaupell’s director of business development. “We purchased this machine in response to existing customer needs and hope to fulfill the needs of other customers.”

The Agawam facility manufactures components and subassemblies for the medical device industry, including pipette tips that it fabricates in a fully automated cell. The cell includes 100% electronic inspection, defect replacement, racking in trays, and packaging. The company also provides in-house mold building and precision machining capabilities for custom fixtures and gauges. Its molding capabilities include cleanroom molding and assembly, scientific injection molding, and a variety of secondary and bonding operations.

The Healing Power of Nanodiamonds

Wednesday, July 29th, 2009

A team of researchers at Northwestern University is dazzling the industry with a drug-delivery development that pairs insulin with nanodiamonds. Resulting clusters composed from the novel nanosized materials and therapeutic agent could aid in fighting bacterial infections and facilitating healing in wound-care applications.

The researchers found that the high surface area of nanodiamonds allowed for the bonding of ample supplies of insulin, which can be released on demand at a specific location. Release of the insulin is triggered when the cluster encounters  alkaline pH levels often found at wound sites during the repair and healing process, according to the researchers.

“This study introduces the concept of nanodiamond-mediated release of therapeutic proteins,” explains Dean Ho, assistant professor of biomedical engineering and mechanical engineering and research leader. “It’s a tricky problem because proteins, even small ones like insulin, bind so well to the nanodiamonds. But, in this case, the right pH level effectively triggers the release of the insulin.”

The insulin-nanodiamond drug-delivery method has potential for use in such applications as gels, ointments, bandages, and sutures.

The study can be found in the July 26 issue of Biomaterials.

Surface Acoustic Waves May Revolutionize Drug Delivery

Tuesday, July 28th, 2009
Acoustic waves are created to form fluid jets.

Acoustic waves are used to form fluid jets.

Researchers at Monash University (Victoria, Australia) have been developing a novel method for forming a fluid jet from an isolated droplet. Led by Leslie Yeo, the team has harnessed surface acoustic waves (SAWs) to transport fluids, opening the door to revolutionizing medical device applications.

Fluid jets are generally created by forcing a liquid through a small opening. But in microfluidics, it is challenging to manipulate small amounts of fluid because of high surface tension. Many microfluidic devices must be attached to a big pump, resulting in an unwieldy and inefficient device.

Yeo and his colleagues hope that SAWs will overcome this limitation. Tiny versions of seismic surface waves, SAWs have amplitudes that can be just a few nanometers. In microfluidic applications, they can be used to vibrate and break up droplets.

In their work with SAWs, the researchers put two electrodes on a lithium-niobate piezoelectric surface, a material that converts electric voltage into SAWs. Made from arrays of curved metal strips, or arcs, the electrodes took up two 90° sectors of a disk-shaped object with a hole in the center. The arrays focused SAWs from opposite directions into the center, which contained a 1- to 5-µl drop of water, ethanol, methanol, or octanol.

At a frequency of 30 MHz, the vibrations triggered different behaviors in the droplets, depending on the vertical acceleration of the waves, which the team controlled with slight changes in amplitude. At smaller amplitudes, the force wasn’t strong enough to overcome the droplet’s surface tension, causing it to oscillate in place. At larger amplitudes, the droplet erupted into a jet 1 to 2 cm high, reaching speeds of several meters per second. The larger the SAW amplitude, the longer the jet. At even higher amplitudes, the jet broke up into a series of smaller droplets. The largest SAWs caused the droplet to form even tinier droplets, a process called atomization.

The next step for Yeo and his team is to learn how to control the jets. Precise control may enable the technology to be used in future medical device applications such as drug delivery devices.

Wireless Technology Leads the Charge for Implants

Monday, July 27th, 2009

Battery life, in many instances, has been a bane for patients with electronic implants. When an implantable device such as a pacemaker or defibrillator has low battery life, the device typically must be explanted and replaced so as to avoid device failure resulting from loss of power. But WiTricity Corp. (Watertown, MA) is hoping to change this bothersome (and potentially dangerous) norm. The company’s technology can provide direct wireless power interconnections and automatic wireless charging for implantable medical devices.

Named as one of the 10 technologies most likely to change the way we live for 2008 by MIT’s Technology Review, WiTricity technology was demonstrated at the TED Global Conference in the UK last week. Designed for OEM integration, the technology entails the use of magnetic resonators to transfer power across significant distances  by way of the magnetic near-field, according to the company.

“A transformer is really two coils with wire placed very close together where the electricity does move for very short distances,”  Eric Giler, chief executive of WiTricity, explained to BBC News. “About two and a haf years ago, a professor at MIT figured out how to separate the coils in a transformer in such a way that you’re able to transfer power safely and efficiently across much greater differences, which makes it possible to power virtually anything that requires either a wire or a battery.” Among the potential applications for the technology is the wireless recharging of electronic implants.

A video of Giler speaking about the technology can be found on the BBC News Web site.

CDS Launches Medical Tubing Extrusion Equipment Line

Friday, July 24th, 2009
The CDS downstream medical tubing extrusion line includes a vacuum sizing tank, cutter unit, and takeaway conveyor.

The CDS downstream medical tubing extrusion line includes a vacuum sizing tank, cutter unit, and takeaway conveyor.

Extrusion machinery provider Custom Downstream Systems Inc. (CDS; Lachine, QC, Canada) has launched a new line of downstream extrusion equipment for medical tubing applications. The line includes a high-precision vacuum sizing tank, a combination servo belt haul-off and servo fly-knife cutter unit, and a takeaway conveyor.

Designed to provide the precise shaping requirements of medical tubing applications, the vacuum sizing tank, model CMPVS 8-8, features an efficient water cooling system and high heat-transfer rate. To maximize operator control and reduce downtime, the tank is constructed with exterior product-support rollers, retractable water reservoirs, and water-level adjustment functions. These features enable the operator to make adjustments to the machine without halting production. Horizontal and lateral movement of the tank is controlled by manual knobs, but the unit also allows three-axis movement via a PLC.

The model CMCBSSK 2-125 combination servo belt haul-off and servo fly-knife cutter unit features cut-to-length and x-y cutter adjustment designed to provide high accuracy and pulling capabilities. It has a maximum cut length of 254 m, minimum cutting capacity of 0.254 cm, and offers a cut-to-length accuracy of ±0.03 cm. To ensure overall quality and consistency, the unit has an integrated lubrication system and the machine also includes an easy blade-replacement channel for operator safety.

To efficiently collect extruded products, the model CMTC 4-10 takeaway conveyor is designed with an adjustable frame that has front-mounted controls, which allow for independent line speed adjustments within a 39-45-in. range. Such adjustment capability can reduce product-collection costs while increasing overall productivity, according to the manufacturer. Monitoring of the unit’s speed is made easy with a control that indicates the conveyor’s movement in feet per second. The machine also has a pneumatic ejector that discharges to a product collection tray and exterior ribbing designed to reduce the risk of residue accumulation.

Argotec Restructures TPU Film Business to Better Serve Medical Device Industry

Friday, July 24th, 2009
Argotec's sterilizable TPU film products offer softness and breathability characteristics that make them suited for use in medical device and wound-care applications.

 TPU films offer softness and breathability characteristics that make them suited for use in wound-care applications.

To better serve the medical device and wound-care product manufacturing industries, Argotec Inc. (Greenfield, MA) has restructured its thermoplastic polyurethane (TPU) film business. The company is taking a more application-oriented approach to the way it bundles groups of like products and resources.

“Instead of focusing just on products we can make and market, we are concentrating on better matching our film extrusion capabilities, technical expertise, and resources with the applications of our customers,” says Bruce Wilby, Argotec president and CEO. Recognizing a trend among medical product manufacturers of increasingly using polyurethane films in conversion, fabrication, and pressure-sensitive adhesive coating processes, the company is highlighting the performance characteristics of its Argomed TPU products that are suited for those applications.

Converters, fabricators, and manufacturers are specifying TPU film for medical device and wound-care products because of its high rate of moisture-vapor transpiration breathability, softness, and stretchability, according to the company. Available with antimicrobial infection control technology, the company says its TPU film and sheet products contain no plasticizers that can cause allergic reactions in patients or make a product more brittle, which can reduce its potential shelf life. Compatible with most commercial adhesive systems, the TPU films also can withstand multiple commerical cleanings as well as EtO, gamma, and autoclave sterilization. The company can extrude TPU in film and sheet thicknesses ranging from 0.2 to 125 mm and widths up to 86 in.

The restructuring is also a response to customer requests for a film supplier that can act as a partner in solving specific application challenges. “We feel that the investments we have made in equipment, facilities, along with restructuring our business in a way that allows us to more effectively focus those resources on solving customers’ design and production challenges, is a clear answer to that call,” Wilby says.

Precision Medical Products Expands Cleanroom Services

Wednesday, July 22nd, 2009
Precision Medical Products offers portable Class 10,000 cleanroom services for injection molding applications.

Precision Medical Products offers portable Class 10,000 cleanroom services for injection molding applications.

Precision Medical Products Inc. (Denver) has continued to expand its cleanroom manufacturing and assembly services to include Class 100,000 and Class 10,000 capabilities since building its production facility four years ago. Customer demand has been driving the company’s focus on such services, explains George Weaver, vice president of marketing. “More and more customers want to purchase a turnkey product including packaging and sterilization of their medical devices,” he says.

The company, which manufactures devices and needles for cardiovascular, orthopedic, drug-delivery, and other applications, offers molding and welding in addition to assembly and packaging services. It also can provide washing of components and assembled products and recently added simulation molding services for plastic and thin film applications.

As demand for injection molding services has increased, the company also has made portable cleanroom manufacturing and packaging services available. “Mobile cleanrooms may be applied in manufacturing where cleanrooms don’t exist,” says Weaver. “It’s a portable tool that we are using for specific injection molding operations that require a Class 10,000 environment.”

Minnesota Sees Sizeable Slice of VC Funding

Tuesday, July 21st, 2009

Despite the economic turmoil plaguing the nation, Minnesota’s medical device industry has managed to nab a fair share of investment dollars in the second quarter, according to reports. Venture capital (VC) funding contributed $96.9 million to 10 local companies. Although significantly off-pace compared with last year, these figures demonstrate a promising upswing in investment from the $56.2 million received by five companies during the first three months of the year, states a MoneyTree report by PricewaterhouseCoopers and the National Venture Capital Association.

Almost $75 million of the funds were funneled into medical device start-up companies, which is a dramatic gain from the first quarter. The biggest surprise from the report, however, is not the uptick in investment (although likely welcome), but in the companies that are receiving the funds. The Twin Cities have long been recognized as the heart of the cardiovascular device sector. But perhaps change is on the horizon in the form of diversification: Only one of the seven start-ups that received funding is currently working on a cardiovascular technology. Instead, investments went to companies developing products for such market segments as orthopedics, sleep disorders, neurological disease, wound care, and digestive disorders.

“Most of the deals we’ve had in this town started with cardiovascular devices,” Jay Hare, a Minneapolis-based PricewaterhouseCoopers analyst, told the Star Tribune. “But the cardiac market has matured; it’s not quite the Wild West it used to be. We are starting to diversify into other areas of medical technology. That’s encouraging, because it means Minnesota is apt to stay strong in the medical arena.”

Is Minnesota gearing up for a changing medical device landscape? We’ll have to wait and see.

Transducer Technology May Help Shrink Ultrasonic Cutting Devices

Monday, July 20th, 2009

Researchers from three UK universities are developing a transducer technology that does not operate in resonance, allowing the design of smaller ultrasonic cutting instruments. The goal is to create devices that surgeons will be able to use to perform minimally invasive procedures on delicate areas of the body such as the spine.

Current ultrasonic cutting devices consist of a Langevin piezoelectric transducer attached to a cutting blade that is tuned to resonate in a longitudinal mode at a low ultrasonic frequency. “The current systems have to be resonant, which means to maximize the vibrations you must create a device that is tuned to the frequency you’re operating at,” remarks Margaret Lucas, a mechanical engineer from the University of Glasgow in Scotland, who is leading efforts to develop the transducer.” Once it is tuned, it dictates what size the device has to be.”

Because the length of the tuned blade must be designed a half-wavelength or a multiple of the half-wavelength of the frequency driving the system, cutting instruments based on this technology must be relatively large. To overcome this size issue, the UK researchers are developing ultrasonic cutting instruments that will incorporate flextensional transducers. A flextensional transducer consists of piezoelectric rings bonded to two endcaps. When a voltage is applied, the ring contracts radially and the endcaps flex, providing an amplified longitudinal motion.

Lucas and her colleagues have proposed attaching the cutting blade to one of the vibrating endcaps, causing the blade to behave like a rigid body without having to be a tuned component of the device. “Basically it would not rely on being resonant,” Lucas explains. “It takes away that limitation in terms of the size and geometry of the device.”

The researchers think that the blade of a cutting device based on a flextensional transducer can be tailored to provide better interaction between the blade and the bone than the current technology, resulting in more-accurate incisions. It will also allow the overall ultrasonic device to be miniaturized.

“The devices will be used in orthopedics probably for spinal procedures and surgeries to the face,” Lucas remarks. “There are a lot of procedures that currently cannot be accessed by minimally invasive methods, and we are hoping this will be possible with a small and very accurate ultrasonic device.”