Originally Published EMDM November/December 2002
PRODUCT UPDATE
Adhesives Research Ltd.
Developed for molecular technology applications, low-fluorescence adhesives enhance signal detection in such products as microfluidic devices, microarrays, bioassays, and multiwell and microplate platforms. They are designed for manufacturers who use adhesives as critical bonding tools but want to avoid interference with fluorescence detection, according to Adhesives Research Ltd. (Great Dunmow, Essex, UK).
Fluorescence detection and measurement are critical when analyzing chemical and biological materials. The devices used typically require a cover to isolate the assay components from the environment. However, the device components and the chemical structure of the cover film may have an effect on fluorescence measurements. If not designed specifically for such applications, the pressure-sensitive adhesive that is used to bond the cover film to the assay device may also affect background fluorescence and, consequently, sensitivity. Addressing these important concerns, Adhesives Research has developed low-autofluorescence sealing constructions and adhesives. Used alone or in conjunction with a low-fluorescence assay platform or multiwell plate, the adhesives can reduce undesirable background fluorescence occurring at the wavelength used to detect the biomaterial during the assay.
Other features of the products include dimensional stability, an absence of voids or gaps, and stability in the presence of moisture or temperature variations. The adhesives are compatible with electrophoretic separation and can dissipate heat during this process.
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